Amino Acid Neurotransmitter Levels in the Cerebral Cortex of Mice Receiving Imipenem/Cilastatin -Lack of Excitotoxicity in the Central Nervous System
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چکیده
495 Abstract: Imipenem, a very potent carbapenem derivative beta-lactam antibiotic, has recently found a major place in the treatment of antibiotic-resistant nosocomial infections. However, a convulsive side effect is seen in 0.2-3 percent of patients. Although it is suggested that this effect is due to the inhibition of gamma-aminobutyric acid (GABA) mediated inhibitory transmission, no study has been reported so far showing its effect on the cerebral cortex free inhibitory and excitatory amino acid levels.
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تاریخ انتشار 2000